Posted by Cam W. on August 27, 2001, at 1:54:13
In reply to Re: Olanzapine and side effects Distressed, posted by N_Oracle on August 26, 2001, at 21:41:13
N - The weight gain with Zyprexa™ (olanzapine) is seen in approximately 70% of people taking the drug. The weight gain seems to level off after about 8 to 12 months.
Some of the weight gain seems to be related to increased carbohydrate craving, but other factors (leptin levels, baseline Body Mass Index [BMI], concentration of serotonin-2C receptors, antimuscarinic, or antihistaminergic effects etc.) also seem to be involved. To my knowledge, there has been no scientifically reproduceable conclusions as to the definitive mechanisms of Zyprexa-induced weight gain.
I hope that this is of some help. - Cam