Posted by Cam W. on August 6, 2001, at 14:39:23
In reply to Can anyone give reassurance re: Geodon and nausea?, posted by grapebubblegum on August 6, 2001, at 9:53:25
GBG - The nausea from SSRIs is due to stimulation of the serotonin-3 (5-HT3) receptors in the gut, and possibly due to direct irritation of the tummy.
As for Geodon, I do not have the receptor binding profile in front of me (am at home - Canadian holiday, eh). I would suspect direct irritation of the stomach by the drug, but could be due to the blocking of dopamine-2 (D2) receptors.
Dopamine and serotonin control each others levels in the body (along with the help of many other neurotransmitters and neuromodulators), so when you block the D2 receptors with the Geodon, the serotonin levels "may" increase. This increase in serotonin "may" be stimulating the 5-HT3 receptors in the gut (Geodon blocks 5-HT2 receptors, but I am not sure to what extent it blocks 5-HT3 receptors).
If no one offers a better explanation before tomorrow, I will check my files at work and see if I can figure out the nausea mechanism. In either of the mechanisms that I have guessed at, bland, bulky foods (eg crackers) would minimize the discomfort.
I hope that this is of some help. - Cam
poster:Cam W.
thread:73765
URL: http://www.dr-bob.org/babble/20010804/msgs/73820.html