Re: mirtazapine » PaulB

Posted by Mitch on August 5, 2001, at 15:40:14

In reply to mirtazapine, posted by PaulB on August 5, 2001, at 14:30:20

> I wanted to find out peoples opinions on the main mechanism by which Mirtazapine acts as an antidepressant. Believe it blocks receptors called alpha2-autoreceptors and alpha2-heteroreceptors but was wondering how significant blockade of the other receptors was. You see ive been reading that theres an increased interest in drugs that block post-synaptic receptors as antidepressants. Just wondering how significant people thought this was in mirtazpines antidepressant action.
> Thanks
> PaulB
The receptor targeting and blockade of alpha2 adrenergic receptors and 5-HT2a,c and 5-HT3 serotonin receptors is its primary means of antidepressant activity. Through doing so, serotonin and norepinephrine functions are both "enhanced". SalArmy4me or Elizabeth or Sunnely, or Cam W. could better enlighten you on
the details, though.
Mitch

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mirtazapine PaulB 8/5/01
Re: mirtazapine » PaulB Mitch 8/5/01

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