Posted by jackiechan on August 2, 2001, at 1:54:52
In reply to Re: Cyprenil (L-deprenyl) with Manerix (moclobemide)? » jackiechan, posted by SalArmy4me on August 2, 2001, at 1:45:44
> You need a two-week washout period: http://www.dr-bob.org/tips/split/Switching-to-and-from-MAOI.html
Thanks, the link you gives an even more specific answer for moclobemide. Half life is quite short. It seems for this particular one 2 days might work?
Moclobemide, a RIMA (reversible inhibitor of monoamine oxidase), is far safer than the classical and irreversible MAOIs (tranylcypromine or phenelzine) relative to drug/food interactions. This has been demonstrated with tyramine administration in healthy volunteers as well as with experiments in animals. However, moclobemide does increase serotonin levels for 24 hours after a single dose in the rat brain. With repeated administration there are no cumulative effects in contrast to the classical MAOIs. The half life of moclobemide is short (around 3 hours), but irrespective of this it is safer to wait 48 hours after the last dose of moclobemide before switching to fluoxetine.
--------------------------------------------------------------------------------
poster:jackiechan
thread:73029
URL: http://www.dr-bob.org/babble/20010731/msgs/73038.html