Posted by SalArmy4me on July 19, 2001, at 0:32:28
In reply to Zoloft Dangers (help), posted by help on July 19, 2001, at 0:28:14
I once took 400 mg of Zoloft per day and turned out alright.
Date: Mon, 15 May 1995 22:13:39 +0059 (EDT)
From: email@example.com (Stanley Cole)
Subject: SSRI maximum doses
On Mon, 15 May 1995, Sergio Henao wrote:
It has been said in this group that patients sometimes respond to SSRI doses beyond the usually recomended ones. For instance, sertraline has been given in doses of up to 600 mg a day with success. I checked with some of my colleagues (psychopharmacologists) in Houston and they never heard of it and would not recomend it. In view of this I decided to call the medical information department at the manufacturing company. Their physician told me that for that particular drug the response curve has been flat and for this reason they would not recomend or support going beyond 200.
I have a number of patients who respond only to relatively high doses of SSRIs. One patient walked in one day and finally reported relief from his depression only after reaching fluoxetine 120 mg qd. I have other patients on sertraline who respond only to 350 mg. I have checked levels frequently to see if I was really giving toxic doses of meds, but the combined levels (including the nor-metabolite) were relatively low. Either these are rapid extensive metabolizers, or they are not absorbing the meds or there is an unmearsured metabolite that is very high. (These are patients whose compliance I trust.)