Posted by Mitch on July 18, 2001, at 0:19:36
In reply to Re: Levitiracetam Zonisamide anybody tried them?, posted by susan C on July 17, 2001, at 14:21:41
SusanC,
Thanks for the info! I got confused clicking around as to who posted it. It seems Keppra appears to have fewer cognitive adverse effects than Zonegran. The animal studies with enhanced-memory-well I will have to look into that one a little closer. I also found a medscape article that was discussing the mechanisms of AED's and mentioned that Keppra almost was excluded because it *failed* the "maximal electroshock test" that triggers generalized (grand mal) seizures and is commonly used to screen new AED meds, however it does *abolish* seizures brought on by a newer test (designed and modeled for partial seizures) that is a "6Hz corneal stimulation model of pharmacoresistant partial seizures". Anyway, here is a link for anyone who can get into Medscape-it is an interesting article!
http://pharmacotherapy.medscape.com/CMECircle/Neurology/2001/CME02/CME02-17.htmlMitch
> http://www.bipolarnetwork.org/new_site/Clinical/ on this site, is Levitiracetam study. My pdoc mentioned it as something up and coming to investigate. I haven't taken it.
>
> > Hey, has anybody tried these? The two newest ones are zonisamide and levitiracetam. They are marketed in the U.S. as Zonegran and Keppra.
> > I posted a Zonegran thing once before, but got no replies. My pdoc mentioned Zonegran a few months ago, but I was wary about switching/adding anything at that time.
> >
> >
> > > Three new anti-epileptics are out:
> > > Zonisamide
> > > Tiagabine
> > > Levitiracetam
> > >
> > > There's also the standard ones, which I can probably find a list of if you need it.
poster:Mitch
thread:70361
URL: http://www.dr-bob.org/babble/20010714/msgs/70582.html