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Re: Depakote, Klonopin, Wellbutrin » Peter

Posted by Mitch on July 12, 2001, at 13:13:51

In reply to Re: Depakote, Klonopin, Wellbutrin, posted by Peter on July 12, 2001, at 12:24:32

> > Hi Mitch - thanks for the follow-up. I'm encouraged to hear that Wellbutrin helped, instead of exacerbated, your social anxiety. I'm looking forward to baing able to go out more and do stuff without being so overly self-conscious. Also, I'm curious to know about the Wellbutrin counteracting Depakote weight gain. I've heard from so many people that they lost weight on Wellbutrin. Finally, I just wanted to ask you about klonopin. How long have you been taking it and what daily dose? The reason I ask is I have been on it for about 3 years. When I began it it did wonders for my social phobia - especially in talking situations like you said. But since then it began to make me more tired, spacey, and "inward," so I had to reduce the dose. I used to take up to 2 mg per day and now I only take .25 during the day to take the edge off without making me spacey and .5 at night to help me sleep. I'm curious if you've maintained the social-phobia benefits of klonopin and how?

Peter,
I started off with 1.0 mg/day and I have been up to 1.5mg/day, and now *back* to 1.0mg/day off and on (mostly on) for the last three years like yourself. Yes, I did notice the pronounced pro-social effect it had right off when I started it, it is still with me I just don't notice the difference as much (because I am used to it). I have not had any full-blown panic attacks while I have been on it-so that's good enough reason for me to continue it.

I think what is happenening to you (as far as being tired and unmotivated) is your Depakote dosage. I *never* got much of an AD effect from Dep. I *do* with Neurontin, however (at lower doses). 875mgs is actually quite a lot if you haven't ever had a full-blown manic episode. I have heard people bitch a lot here about 750mg. I never needed more than 500mg/day to keep hypomania away. This is just a hunch..but what if you could swap out some Depakote for some Neurontin instead and see if it helps (of course with the *same* Klonopin/Wellbutrin dose)?? I found 600/day of Neurontin really helped the SP and 300/day has an AD effect for me. However if I went 900mg+ I got tired and sleepy.

Depakote may be *potentiating* the *unwanted* side-effects of your Klonopin, so you may have went down with the Klonopin (to "wakeup") and your SP got worse.

My bottom line-get the Depakote dose down some, and perhaps the Klonopin back up a little. Try the Wellbutrin with it and see how it goes. I have heard that Wellbutrin can really kill your appetite (I noticed that too), while we know how HUNGRY you can get on dep. It might work ok.

good luck
Mitch


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