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Re: Selegiline + Pemoline: is it safe? » Jean Paul

Posted by SalArmy4me on June 10, 2001, at 18:46:35

In reply to Selegiline + Pemoline: is it safe?, posted by Jean Paul on June 10, 2001, at 17:40:32

From the Drug Checker at www.drkoop.com:

1. Severe Interaction between pemoline and selegiline

Amphetamines may precipitate severe hypertensive reactions in patients taking MAOIs. MAOIs cause an increase in norepinephrine storage in adrenergic neurons. Amphetamines liberate catecholamines resulting in an exaggerated effect in patients taking MAOIs. Death has been reported. Patients should be counseled to avoid concurrent use of MAOIs and amphetamines (and related drugs).

References:
1. Cuthbert MF, Greenberg MP, Morley SW. Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors. Br Med J. 1969;1:404-6. more info
2. Dally PJ. Fatal reaction associated with tranylcypromine and methylamphetamine. Lancet. 1962;1:1235-6.
3. Elis J, Laurence DR, Mattie H, Prichard BN. Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure. Br Med J. 1967;2:75-8. more info


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URL: http://www.dr-bob.org/babble/20010605/msgs/66060.html