Posted by jodsteroo on June 8, 2001, at 19:14:25
In reply to Topamax and Cognition » super, posted by SalArmy4me on June 8, 2001, at 9:57:04
> Markind, Jan E.. Topiramate: A new antiepileptic drug. American Journal of Health-System Pharmacy. 55(6):554-562, March 15, 1998:
>
> "There have been concerns about topiramate's cognitive effects; topiramate may be similar to carbamazepine in that large doses are not well tolerated initially. Privitera assessed cognitive function during a long-term, open-label study of 15 patients who underwent cognitive testing at each clinic visit (monthly for six months and then quarterly). The following tests were administered: recall-memory for three items at three minutes, attention-counting backward from 100 by sevens, and word fluency-naming as many words beginning with the letter "h" as possible in 30 seconds. Baseline scores were compared with one-year scores or scores at the highest dosage of topiramate. Patients were followed for a mean of 14.9 months (range, 4-24 months). The mean dosage was 887 mg/day (range, 300-1600 mg/day). For the nine patients who remained in the study for a year or more, mean scores on all three tests improved. For the six patients completing less than a year of the study, mean scores on all three tests dipped slightly because of large declines in all test scores for two patients. In summary, in a long-term study, mean scores on brief tests of cognitive function did not decrease with time, although two patients demonstrated decreased scores at the highest topiramate dosage."Can you elaborate a little more on your topimax story...i cant seem to really understand the results?? did topimax's effect on cognition dissipate after time? or was it only seen at high doses?...sorry if i seem rude but i am really interested in this cause the reason i stopped topimax is because it made me feel retardrd..but if that goes away...i would start it again definatly! thanks for your help!...-jodi!
poster:jodsteroo
thread:65644
URL: http://www.dr-bob.org/babble/20010605/msgs/65825.html