Trazadone, Nefazadone and mCPP

Posted by PaulB on June 6, 2001, at 12:17:00

Hello, I am trying to find out more about the differences in the 5-HT2 antagonist properties of the similar antidepressants Nefazadone and Trazadone as I think it may be of relevance in regards to these drugs metabolite mCPP, 5-HT agonist
Nefazadone and Trazadone are both augmentors as well as antidepressants and when augmented with the popular SSRI's Paroxetine and Fluoxetine the levels of the metabolite mCPP can increase to a therapeutic level because the metabolising enzyme P450 CYP2D6 is potently inhibited by both these drugs. mCPP at higher levels would cause antidepressant/anxiolytic effects and 5-HT side-effects too.
What I wanted to find out is whether it is true that Nefazadone is a full antagonist at the 5-HT2 receptors and Trazadone blocks only 5-HT2a. If this were true Nefazadone may well block mCPP which is agonist at 5-HT2c and Trazadone wouldnt block mCPP from acting as an agonist at this particular receptor subtype.

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Trazadone, Nefazadone and mCPP PaulB 6/6/01
Re: Trazadone, Nefazadone and mCPP SalArmy4me 6/6/01
Re: Trazadone, Nefazadone and mCPP PaulB 6/6/01
Thanks for the link » SalArmy4me Jane D 6/6/01
Re: Trazadone, Nefazadone and mCPP » PaulB Elizabeth 6/7/01
Re: Ditto Thanks for the link Lorraine 6/11/01

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