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Re: About Amisulpride/Adafrinil combo

Posted by JohnL on May 11, 2001, at 5:06:33

In reply to About Amisulpride/Adafrinil combo, posted by Anna Laura on May 11, 2001, at 3:14:10

> Hi everybody, hope i'm not bothering with my questions......
> I was thinking about trying the adafrinil/amisulpride combo.I never tried amisulpride.
> I did take an antypsychotic medication some years ago though : it was called "impromen" (brand name here in Italy);don't know the brand name in the U.S. It's a butyropherone derivate ( i think the chemical compound is named something like "bromperidol"); even though i was taking a very low dose it made me feel like a zombie. I felt totally numb and almost catatonic. I held on for six months, but finally i had to quit because i couldn't handle the flattening of the affect.
> Do you think this is a predictive factor, being amisulpride an antypsicotic agent?
> Another question: since i've been psychotic do i run any risks if i take adafrinil which is a stimulant?
> Thanks in advance,
> Anna Laura

Hi Anna Laura,
You ask some good questions. I'm not sure I have the answers, but I am familiar through personal experience with both of these meds.

Neither Amisulpride or Adrafinil should cause the flattening effect. To the contrary, they usually abolish the flattening effect instead. Amisulpride is kind of in a class all its own and is not like the other antipsychotics. At low doses it is kind of like a mild stimulant. Also, even though Adrafinil is called a stimulant, it isn't stimulating in the same way as stimulants. Its effects come on slowly over days to weeks, and are more related to cognitive stimulation rather than bodily stimulation.

There is an outside chance these could cause psychosis, but I doubt it. If it did happen, raising the Amisulpride dose would be the first thing to do. It is an antipsychotic for psychosis, but it only does that at higher doses.

I support anyone giving these drugs a try. They belong to an elite class of drugs that I have observed as being a bit more promising than most. The other drugs in the 'most promising' class, as I see it, are Amisulpride, Adrafinil, Zyprexa, Risperdal, and Prozac. I think the world of psychiatry would be much more successful if treatment was first limited to just these drugs, with other drugs tried only after these failed. I just don't see these fail as often as others.




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