Posted by Sunnely on March 30, 2001, at 23:56:34
In reply to Re: If Zyprexa BLOCKS dopamine, what good is it?, posted by Eric on March 29, 2001, at 9:05:33
The biochemical profile of atypical antipsychotic drugs would suggest the possibility of both anti-manic and antidepressant effects. Dopamine 2 receptor (D2) blockade, as occurs with typical antipsychotic drugs, is associated with anti-manic effects. Serotonin receptor 2 (5HT2) blockade, as occurs with some standard antidepressants (trazodone or Desyrel, nefazodone or Serzone, mirtazapine or Remeron), is associated with antidepressants effects; this occurs by increasing neurotransmission of available serotonin along unblocked serotonin 1 receptors (5HT1), a postulated antidepressant mechanism.
Ziprasidone (Geodon) has a strong potential for antidepressant effect due to the following receptor affinities: 1) potent serotonin 1A receptor agonist (enhancer), 2) potent serotonin 1D receptor antagonist (blocker), and 3) moderate serotonin (5HT) and norepinephrine (NE) reuptake inhibitor, similar to imipramine (Tofranil).
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> > Risperdal, Seroquel, and Geodon do the same thing, so how is that supposed to help someone? Don't we need dopamine in our brains?
>
>
> What I recently read on here is that lower doses of atypical anti-psychotics increase dopamine levels. Whereas the higher levels that are used for true schizophrenia or manic behavior slow dopamine levels down. If I am incorrect about this, please someone more knowledgeable about anti-psychotics correct me.
>
> Low dose neuroleptics increases dopamine levels. High dose neuroleptics decrease dopamine levels? Is this correct?
>
> Eric
poster:Sunnely
thread:57880
URL: http://www.dr-bob.org/babble/20010327/msgs/58172.html