Posted by michael on March 22, 2001, at 23:55:08
In reply to Re: Andrew, re: mirapex... one more time, posted by AndrewB on March 22, 2001, at 23:50:31
> Michael,
>
> It to be expected that at low doses Pramipexole acts as an antipsychotic and an AD at higher doses, just as the inverse is true of amisulpride. The dosages recommended for its use as an AD (i.e. 5mg./day) are high doses and it definatley doesn't act as an antipsych. at those doses.
>
> Just one note, the presynaptic autoreceptors have a stronger binding affinity than the postsynaptic, but they get filled up with rather small does of a D2/D3 meds. That is why at low doses amisulpride and pramipexole latch onto the autoreceptors but at higher doses those receptors are full and the meds then start hitting the postsynaptic receptors.
>
> AndrewB
poster:michael
thread:57230
URL: http://www.dr-bob.org/babble/20010319/msgs/57238.html