Posted by steve on March 16, 2001, at 1:33:46
In reply to Causes of Tardive Dykinesia, posted by JohnX on March 16, 2001, at 0:33:05
>
> Just thought I'd drum up some quick thoughts
> or links on TD causes.
>
> My primary understanding of what causes TD particularly in the older neuroleptics (anti-psychotics), is that chronic D2 antagonism in the nigrostriatal pathway will cause spawning of new D2 receptors to couteract this. Sometimes when the neuroleptic is removed, the body is unable to "undue" the D2 receptors it has spawned, and this can cause the hyperkinetic movement disorders in TD.
>
> Are there other know hypothesis/causes for TD?
>
> -JohnMy understanding is that your hypersensitivity theory is generally regarded as being outdated. Otherwise they wouldn't be looking into antioxidants as a prophylactic. The damage does seem to be structural, as D2 agonists don't cause it.
S.
poster:steve
thread:56627
URL: http://www.dr-bob.org/babble/20010310/msgs/56628.html