Posted by SLS on March 2, 2001, at 8:58:31
In reply to Re: How does Wellbutrin work ?, posted by JohnX on March 2, 2001, at 3:50:03
> I read an article which debated the mechanism of action of Wellbutrin based off of experimental data. The conclusion was that the metabolite hydroxy-bupropion (as Stahl indicates) does most of the work via norepinephrine re-uptake. In the animal models at therapeutic doses, the dopamine reuptake was insignificant. However, they did hypothesize that an unknown genomic mechanism was responsible for increasing the sensitivity of dopamine receptors in the nucleus accumbens.
Dear JohnX,Thank you. This seems very reasonable.
The involvement of NEergic activity has been suspected by many for a long time, but the mechanism remained elusive. Who would have thought to be smart enough to test active metabolites? ;-)
The nucleus accumbens think is very exciting.
> How well the animal models correlate to people
> is a good topic of debate.It depends on the glue.
(Stupid, I know, but I smiled, and that's all that counts).
:-)
- Scott
poster:SLS
thread:54696
URL: http://www.dr-bob.org/babble/20010302/msgs/55326.html