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Re: Differences between Wellbutrin and Wellbutrin SR? terra miller

Posted by JohnX on March 2, 2001, at 4:23:11

In reply to Differences between Wellbutrin and Wellbutrin SR?, posted by terra miller on February 26, 2001, at 21:23:46

> Can somebody tell me or provide a link where I can research the differences/effects/side-effects of Wellbutrin (the plain old thing, compared to the SR version)?
> I'm taking Well. SR now, but I seem to be metabolizing it faster than usual (pdoc's thoughts) and if 100mg twice a day doesn't work, he thinks 75mg might be the next option to try though it is not SR.
> Thing is, Well. SR doesn't feel SR to me. I feel it the whole time. I can tell when it kicks in, when it peaks and when it is declining below acceptable levels. It's a total bell-curve.
> I am stabilizing on the Well. SR and liking it, except for the hypothermia/sore hands and eye strain. (The eye strain side-effect is familiar from my time on serzone.)
> Thanks for the input, again.
> Terra


I had the same eye-strain effect with Wellbutrin

I'm not sure how the SR version works vs
the non-SR version. The reason the SR version was introduced was because the elimination time for the non-SR Wellbutrin was fast, thus requiring
multiple dosing during the day. The SR version was introduced to reduce the dosing schedule and
help to maintain a better steady state
level in the blood stream. In rare cases for
anorexics they found that the original Wellbutrin
may induce seizures due to spikes in the absorbtion in the blood. That was also a motive to design the SR version.

I went to their website,
but couldn't find the PDR for the non SR version.
Here is the PDR for the SR version:

Many times the clearance of a drug can be influenced by interactions with other medications that you may be taking? Are you taking anything else? This occurs because the amount of enzymes in the liver that metabolize the drugs can change.

I'm very curious as to what mechanism is used in
medications that are sustained released. I'll look into this and see if I can find out any more answers.





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