Posted by SLS on February 28, 2001, at 6:34:31
In reply to Re: Tardive Dystonia Question (Cam W?) » SLS, posted by Cam W. on February 27, 2001, at 19:47:26
Dear Sunnely and Cam,
Thanks for addressing the questions regarding tardive dyskinetic syndromes.
Regarding Risperdal (risperidone), it is my impression that this drug lies somewhere between clozapine and the typical antipsychotics (Haldol) with regard to EPS and tardive dyskinesia. Whenever I browse Medline for antipsychotic related material, Risperdal pops up most often as the "atypical" that produces these conditions. There seems to be many more anecdotal reports for Risperdal. This is probably due, in part, to Risperdal being around longer than Zyprexa (olanzapine) and Seroquel (quetiapine). However, this trend also makes itself evident in controlled studies investigating other APs. In addition, of the atypicals, Risperdal is the one known to significantly produce increased secretion of prolactin in a way similar to the older drugs.
Does Risperdal possess the highest binding affinity for DA D2 receptors of the atypicals?
I like Risperdal and think it is an amazing drug for many people.
How would you guys rate the risk of EPS and TD for different dosages of Risperdal?
0.5mg
1.0mg
2.0mg
6.0mg
12.0mg
Thanks.- Scott
poster:SLS
thread:54845
URL: http://www.dr-bob.org/babble/20010221/msgs/55077.html