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Re: Anxiety from SAMe

Posted by BillK on February 23, 2001, at 22:38:42

In reply to Anxiety from SAMe, posted by Kennnn on February 23, 2001, at 3:45:54

> I started taking SAMe about twelve days ago, and found it to cause jitters and anxiety on two pills (200mg ea) a day. I am careful to take the pills on an empty stomach, taking the second dosage around 5:00 pm. Being familiar with numerous antidepressants and their side-efects, I was surprised to find these effects of SAMe to be so signifigant. Has anyone found these side-effects to subside in time or figured out how to combat them while still getting the possible benefits. I am, and have been taking multiple vitamins and weekly injections of B12 along with daily B1 for about 4 months now. Any suggestions? I will reduce the SAMe dosage to one pill daily first thing in the morning for now.

I had the same experience taking the same dose of SAMe (400 mg) when I gave it a trial. After six or seven days I developed the uncomfortable inner restlessness. I think that it is sometimes called akathesia. I was familiar with this feeling from other psychiatric drugs that I had taken such as Wellbutrin.

I didn't persist with it because I have learned to avoid drugs that cause this sensation. But I was impressed that SAMe had caused a side effect like a real drug, not like a food supplement. I thought that those who do well on activating antidepressants maybe should give SAMe a try.




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