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Re: Re; psychopharmacology of lamictal

Posted by JohnX on February 11, 2001, at 11:10:38

In reply to Re; psychopharmacology of lamictal, posted by Ted R on February 11, 2001, at 10:38:34

> > I am familiar with the suggested mechanism on how lamictal stabilizes seizure activity, by possible inhibition of sodium channnels, and a probable modulating effect on release of glutamate and a couple other excitatory amino acids. My question is though, what is it that accounts for lamictal's AD effect? How does lamictal effect Serotonin, Norepinephrine, and Dopamine. Would be interested in hearing from anybody on this area, as I started the drug a couple of weeks ago. I can't seem to locate any description of a medical hypothesis, in regards to the drug's antidepressant effect...Thanks...Ted

Ted-

I've dug every where possible to see if the
scientists have a clue as to why lamictal
has good anti-depressant effect.

The only thing I could find was some
unsubstantiated data that it was a weak
reuptake inhibitor of either serotonin,norepinephrine,
or dopamine. Don't remember the details.

I don't think anybody really knows yet.
But I'm certain the medical community
is quite interested in finding out.

-john



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poster:JohnX thread:53739
URL: http://www.dr-bob.org/babble/20010131/msgs/53744.html