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Re:Amisulpride Update #2

Posted by AndrewB on February 2, 2001, at 0:08:45

In reply to Re:Amisulpride Update #2, posted by Katz on February 1, 2001, at 16:33:35

Katz,

First of all I would like to suggest that you not get your expectations up too high about any one med. You never know what is going to work. The best avenue to success is patience and willingness to try various med. (combo.s). But chances are, with time, you will find the right med.

Sedation is one the most common sided effects among non-responders to amisulpride. Usually, but not always, it does not go away.

I suggest you try amisulpride at your current dosage for a total of 5 days.

Since we know too high doses of amisulpride cause sedation, if the sedation persists, after five days switch to taking 12.5mg.s of amisulpride at night. Give this trial 5 days. If you are still sedated or unresponsive it is time to try something else.

It is possible that the sedation in this case is caused by supersensitive and very responsive postsynaptic dopamine D2/D3 receptors. The receptors may be so sensitive they are attracting amisulpride, even at low doses to attach to them. When this happens the amisulpride will block these receptors and can cause sedation and tension.

This scenario, if applicable, gives us a clue as to what may work for you. Specifically you may benefit from stimulation of those D2/D3 receptors. Mirapex is very effective at doing this, so I would make it my first choice for a trial if amisulpride doesn’t work.

Mirapex is available in the US or without an Rx abroad.

Please keep us informed on how it is going and try to keep the faith that a med. that will help you is out there.

AndrewB



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