Posted by JohnL on January 20, 2001, at 3:36:56
In reply to New here - questions about Amisulpride / adrafinil, posted by Vince on January 19, 2001, at 23:49:46
Hi Vince,
Though Amisulpride and Adrafinil have stimulative characteristics, they are not stimulants like Dexedrine. They are different in just about every way I can think of. For example, no addiction, no withdrawal, no dependence, and they take time to work. Unlike stimulants, both Amisulpride and Adrafinil take days to weeks to have any effect. You can feel a regular stimulant coming on an hour after dosing. A&A are longer term meds.I especially like these meds for people like you and me who have tried all sorts of things. These meds seem to cover the bases that were missed with everything else, and their mechanisms are distinctly unique and different than anything else. They are especially good for the type of depression characterized by blahness, anhedonia, lack of motivation, lack of interest, social withdrawal.
I've tried both separately and they both have merits on their own. But for some reason they work so much better together. Some likely things to expect with this combination: renewed interest, renewed motivation, more energy (but not like Dexedrine), somewhat increased mental cognition (in contrast to the dumb-drug TCAs you tried), social comfort, more talkative, more confident, MAYBE a slight dulling of sexual desire (I experience this somewhat, though it's not nearly as bad as the SSRIs), and not-so-good sleep. I'm still experimenting to find a good sleep med. Yet all of these things come on slowly and gradually. Though a slight boost might be felt as early as day 1, most of the benefits really start to accrue around 3 weeks or so, and continue to improve with each passing week.
To make a long story short, neither of these drugs are at all similar to Dexedrine, or to anything else you've tried. They are quite unique. While there are dozens of drugs that have common mechanisms (TCAs & SSRIs = reuptake inhibitors), Amisulpride stands alone. There is nothing else like it. With Adrafinil, there are other alpha-1 agonists, but not that focus specifically on brain receptors involved with mood, attention, interest, and cognition. Most alpha-1 agonists are used for blood pressure treatment. Adrafinil's alpha-1 agonism focuses on psychological aspects, not blood pressure. So it too stands alone. There is nothing else like it. Modafinil is supposedly similar, and they look almost identical in molecular structure, but in reality they are two dramatically different drugs. I've tried them both. I like Adrafinil, I didn't like Modafinil at all. But like I've said before, there is something special and unique about the combination of Adrafinil+Amisulpride. They have been referred to as "kinder gentler stimulants", and in my own experience they have nothing in common with Dexedrine, Ritalin, or Adderall.
John
poster:JohnL
thread:52060
URL: http://www.dr-bob.org/babble/20010111/msgs/52071.html