Posted by SLS on January 13, 2001, at 21:32:12
In reply to Re: SCOTT Resperidone?, posted by Dwight on January 10, 2001, at 20:23:46
Hi Dwight.
> Scott,
> you said you take 1mg of resperidone at bed time. I'm taking .5mg at bedtime along with 50mg trazadone and a little temazepam. I have taken the resperidone earlier in the evening alone and it does seem to make me a little sleepy. I'm also taking paxil and adderal in the day. I have a couple of questions for you. I was under the impression that the resperidal doesn't stay in your system that long; it would be out of your system by the time you wake up.No. The half-life of risperidone is about 20 - 24 hours. This is long enough to allow for once-daily dosing for dosages up to 2.0mg. I don't know at what point twice a day dosing becomes necessary. If you take all of your risperidone at night, you will certainly have enough in your body to exert its full effects until the following night's dosing.
> But are you saying that it has some sort of antidepressant effect during the day.
In some people, risperidone can produce a potent antidepressant effect when combined with other drugs. I don't know how effective it is for depression when used alone. Such an antidepressant effect remains constant throughout the day and night. That is the goal.
> Also somebody said something about combining it with a stimulant; if I took it during the day with adderal wouldn't the two just negate each other?
I can't remember reading of anyone taking both at the same time, but it seems perfectly safe to me. As far as the two negating each other, I think it depends on what disorder is being treated. For instance, to give Adderal to someone who is suffering from schizophrenia, or perhaps mania, the Adderal might make their psychotic symptoms worse. When used for depression, such a combination might be exactly what is needed.
> I'm seriously in need of something for anergia and lack of motivation and would be willing to try the resperidone during the day if there's a chance it might help.
It seems that the effective dosage of risperidone for depression lies in the range of 0.5mg - 2.0mg. My doctor has raised my dosage from 1.0mg to 2.0mg. I think I'm starting to feel better.
I would advise taking it before bed. As I described above, it stays in your system all day long.
> What would happen if I took 1mg along with the adderal?
I don't know. Does your doctor have any experience with this combination? I would also recommend looking into the addition of Mirapex (pramipexole) to Risperdal (risperidone).
> What is the dose of resperidal they use for schizophrenia? much higher? Thanks, Dwight
It is higher. 4mg - 8mg
Risperdal has not been officially sanctioned by the FDA for the treatment of depression and other mood disorders, it is used "off label" successfully for these things. When reading through the drug company's package insert for Risperdal, you will not find an indication for its use in depression. For information regarding the use of Risperdal (risperidone) in schizophrenia, check out the following URL:
http://www.mentalhealth.com/drug/p30-r05.html
I hope I have helped answer your questions.
- Scott
poster:SLS
thread:50862
URL: http://www.dr-bob.org/babble/20010111/msgs/51645.html