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glycine? Re: negative symptoms

Posted by Maniz on December 4, 2000, at 12:35:05

In reply to negative symptoms, posted by Maniz on November 30, 2000, at 17:36:35

Hi,

There is a mention here regarding the use of glycine for negative symptoms in schizofrenia

From http://home.vicnet.net.au/~mecfs/general/goldstein_treatment.html

21. Glycine powder 0. 4 Gm/kg/day in juice or Cycloserine 15 - 50 mg od

(available otc in USA- read potential risks and precautions before prescribing-J. S.)Significantly reduces the negative symptoms in schizophrenia.


I do not know what the supposed risks are or if it will work for other negative symptoms (I guerss no).DMG and TMG are easily available, could they have this effect?.

It seems to act on glutamate. From another part of the article: ...dorsolateral prefrontal cortex lesions may cause glutamatergic hypofunction and may be attenuated by glycine, as are negative symptoms in schizophrenia.



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