Posted by AndrewB on November 24, 2000, at 12:04:46
In reply to Just thought I'd check in..., posted by Adam on November 16, 2000, at 20:51:57
Adam,You take a total of 30mg./day?
I would be curious if an add-on low dose antipsychotic (i.e. zyprexa, amisulpride) would reduce jitteriness and mood instability of selegiline. It is a pet theory of mine that these med.s can, at least sometimes, accomplish this.
I presume the insomnia is caused by night time release of the amphetamine metabolite that selegiline produces. Counter with a short acting D2 blocker at bedtime? Mirapex, a D2/D3 agonist, seems to last about 6 hours and at low doses blocks D2 activity. There are other options too along this line but I just thought I would bring the idea to your attention.
I also wonder what your p-doc thinks the effect would be of slightly lowering your selegiline dose and adding on a COMT inhibitor (i.e. talcopone)?
Best Wishes, glad to hear from you again,
AndrewB
poster:AndrewB
thread:48935
URL: http://www.dr-bob.org/babble/20001115/msgs/49350.html