Posted by Sunnely on November 17, 2000, at 22:17:59
In reply to Re: Alternative to Depakote, posted by tonia on November 17, 2000, at 14:24:35
Oxcarbazepine (Trileptal) is FDA approved as an anti-convulsant. It is chemically similar to carbamazepine (Tegretol) but clinically different. It is the "cleaner" version of Tegretol. During clinical trials comparing Trileptal with placebo, does not appear to show clinically significant difference with regard to weight increase. (Trileptal at 600 mg/day = 1% compared to placebo = 1%; 1200 mg/day = 2% compared to placebo = 1%; 2400 mg/day = 2% comapred to placebo = 1%.)
Compared to Tegretol, Trileptal has:
1. Fewer drug-drug interactions because of its minimal interaction with CYP450 system;
2. Does not induce its own metabolism;
3. No black box warning; monitoring of liver enzymes and blood parameters not required;
4. Quickly and easily titrated
Trileptal is not FDA approved as a mood stabilizer. Most of the studies conducted regarding its effectiveness as a mood stabilizer were outside US.
poster:Sunnely
thread:2774
URL: http://www.dr-bob.org/babble/20001115/msgs/48999.html