Posted by AndrewB on October 22, 2000, at 14:44:18
In reply to Re: Selegeline Patch - Update? » AndrewB, posted by Deborah14 on October 21, 2000, at 22:29:35
Deborah,
Supposedly the drug company with rights to the patch will apply for FDA approval in the first quarter of 2001.
Because the selegiline is absorbed through the skin with the patch, the creation of several metabolites (via the liver) from selegiline is avoided or reduced (i.e. amphetamine).
I realize moclobemide hasn't been effective in a lot of cases. It may however be effective when combined with low dose selegiline. Dr. Goldstein claimed that Tasmar (a COMT inhibitor) was more effective when combined with moclobemide. (COMTs like MAO-Bs prevent the breakdown of dopamine.)
I presume that you recieve benefits from the MOA-B inhibition and the MAO-A inhibition of selegiline, thus my suggestion of combining low dose selegiline with Moclobemide.
Part of the reason selegiline helps you may be because it metabolizes into amphet. and metamphet., but obviously it causes side effects also because of this. Anyway, if you do indeed benefit from the stimulant metabolites of selegiline, you may benefit from a stimulant taken only during the day. It is possible to take stimulant without having side effects. One such stimulant is adderall, a combo of equal amounts of dextroamphetamine and amphetamine.
Of course other things may work better for you for your chronic dysthymia. My dysthymia has been taken away with the combo of low dose amisulpride, low dose selegiline, and adderall. I have no side effects. Amisulpride has had a lot of studies done on it showing it to be efective for dysthymia. For an info piece on amisulpride email me at andrewb@seanet.com. Pramipexole, I theorize may substitue well for amisulpride, in some cases. Several other stimulants may subtitiue for adderall.
I wonder though if you don't require something more than such drugs would offer because you also have major depression. That is why I suggested an MAO-A inhibitor.
AndrewB
poster:AndrewB
thread:46818
URL: http://www.dr-bob.org/babble/20001022/msgs/47092.html