Posted by Leonardo on October 6, 2000, at 7:01:36
In reply to Wellbutrin Making Me Depressed. Help!, posted by JackD on October 6, 2000, at 1:00:42
Hi Jack
I haven't tried Wellbutrin yet, but I had a similar experience to yours with reboxetine (in the UK), and also with Remeron, when taken by themselves. For unknown reasons, I never got any benefit from Remeron in any combinations, but when I tried reboxetine and Paxil, I got a very good response. Paxil is well known for its calming effect, and to some extent the reboxetine combats the sedating effect of the Paxil.
Reboxetine and Wellbutrin both work on noradrenaline (but not serotonin), so I suspect adding an SSRI to the Wellbutrin may do the trick for you too. I never got reboxetine to work well by itself, part from an initial rush which soon wore off. I have also had periods of feeling completely well like you describe, which soon wore off. I am now thinking about dopamine...
I may try Wellbutrin and Paxil next as it happens! (see my first post below)
Leonardo
> I started taking Wellbutrin SR 150 mg once a day for anxiety. When I started using it like a month ago, something just clicked. It felt like whatever was wrong with me was fixed (at least partially). The first few days of taking it I felt like I had TONS of dopamine in me... Hard to explain. I felt totally uninhibited, very good. From then I slowly leveled down to a normal feeling, and then even lower and lower and lower up to this point. I'm now more depressed than I've ever been. I feel normal, can think clearly, have little anxiety, but feel an incredible emptiness. What the f#ck is wrong with my brain?? Everything seems so depressing... I can't stand it. Is it possible the Wellbutrin frees up Dopamine in my brain but I don't have enough Seratonin to properly regulate it? Should I combine Serzone to the Wellbutrin? As always, any advice would be greatly appreciated. Boozing and smoking have been blunted by the WB, so they're of little help. BTW I have ADD and GAD.
poster:Leonardo
thread:45852
URL: http://www.dr-bob.org/babble/20000926/msgs/45863.html