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Re: Soical detachment: Anita

Posted by AndrewB on August 9, 2000, at 10:09:48

In reply to Re: Soical detachment: Anita » AndrewB, posted by anita on August 7, 2000, at 17:32:18

> Hi Andrew,
>
> I have a new theory about dopamine & my irritability side-effect: I wonder if the irritability is caused by the increased noradrenaline that is synthesized from dopamine. Perhaps adding something like clonidine to a dopaminergic med might help... I'm going to look at the differences between the norep and dopamine pathways in the brain today. Any thoughts?

Interesting idea! You could try the clonodine with a dopaminergic. A quick look on the web revealed that it can take away anger attacks with PTSD patients. Tolerance can develop, then one can switch to guanfacine.

Another possiblility is a andrenergic beta bocker like propranolol. Again the net said it helped calm the PSTD patients.

I've been taking a little clonazepam (.5 to 1mg) a few hours before I go to sleep, even though I don't have problems sleeping. I don't know what it all means, but I've been in great spirits lately. The clono. has been used with CFS patients, sometimes a little at night (up to 1.5mgs) makes for better energy during the day. I don't know, maybe it gives some people a better sleep.

I keep on wondering with you, however, if you still don't need another mood stabilizer or calcium channel blocker to go with the lamotrigine. The calcium channel blocker nimodipine sometimes helps as a mood stablizer adjunct. All I can say is that I've tried it and it doesn't have any (nasty) side effects.

These are all just loose ideas though Anita. I wish I could be more of an authoritative resource for you!

>
> I'm glad the selegiline is helping you. I haven't really considered it because of the short half-life of its amphetamine-like metabolite -- I'm very sensitive to that, getting terrible "downs" --- which is what happened with Parnate & Ritalin. BTW, I have a friend who takes selegiline recreationally (2.5-5mg), and he loves it.

I haven't noticed what would seem like any amphetamine like effects with selegiline. Everything is super smooth and natural. Maybe that is because I am taking it with amisulpride.

AndrewB


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