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Re: MB-stimulant monotherapy

Posted by Libby on July 19, 2000, at 12:48:30

In reply to Re: MB-stimulant monotherapy, posted by MB on July 18, 2000, at 20:10:46

MB said...
>Supposedly, unlike amphetamine, which both inhibits reuptake and stimulates release of neurotransmiters, bupropion only inhibits uptake of neurotransmitters. OK, that part I understand. But doesn't cocaine work the same way that bupropion does (inhibiting uptake of NE, 5HT, and DA)? Why is cocaine a stim, and Wellbutrin an antidepressant. <

Cocaine acts more like a stimulant than Wellbutrin, because it stimulates the release of dopamine, as well as inhibiting reuptake. As I understand it, what happens in cocaine addiction is that the body begins to shut down some receptors in response to over-stimulation, which causes withdrawal effects and reinforces the whole addictive process.

http://www.onu.edu/user/FS/tfaulkner/Dopamine.htm#dopamine

L.


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