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Re: Scott » AndrewB

Posted by SLS on July 15, 2000, at 9:00:38

In reply to Scott, posted by AndrewB on July 14, 2000, at 20:34:41

Dear Andrew,

I couldn't get the URL to work.


> Treatment of Depression in the Patient with Parkinson's Disease

> www.mmhc.com/cq/articles/CG9810/tom.html


I stopped taking Provigil. It seemed to affect me the same way it affected JohnL. I actually experienced a small improvement within the first few hours of taking my first 100mg dose. It lasted for about half the day. Then I began to feel kind of spacy or hazy, with the improvement having waned. This weird feeling wore off within 24 hours as I kept a 200mg/day schedule. I was left with a bit more energy, but I experienced a low level anxiety and a dull headache. After four days, however, any increase in energy and cognition disappeared, and I just plain didn't like the way I felt. I cut back to 100mg yesterday and do not plan to take any more. I have begun to feel more like my usual sick self.

I don't know what to do next. That I felt anything positive at all argues in favor of trying adrafinil in the hope that my response to it will reflect the scenario I have seen here on Psycho-Babble. It seems that most people who have tried both Provigil and adrafinil, and who eventually responded well to adrafinil, had had disappointing results with Provigil.

Of course, I would like to know more about the true nature of the liver concerns. The other thing that occurs to me is that if the scientists are right, Provigil may have acted antagonistically with the Lamictal I have been taking. This would involve the opposing effects these two drugs *may* exert on extracellular glutamate levels. I imagine the same interaction might occur with adrafinil. Who knows.

When I experienced the short-lived improvement "blip" from Provigil, I thought it felt like it might complement Parnate. I am hoping that my experience with adrafinil would be positive enough to consider combining it with Parnate. Do you know of anyone who has actually used a combination of adrafinil with an MAOI?

Thanks for the reference. I would be interested to read it if you can locate it again.


- Scott

 

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