Posted by S.D. on June 9, 2000, at 17:14:11
In reply to Social Phobia Cocktail -- WOW!!!, posted by Rick on June 8, 2000, at 0:50:53
>I just hope what some have said about a tendency
>for Provigil to poop out doesn't surface for me.
>
Maybe some of our resident pharmacology/neurochemistry experts can help out, but aren't Klonopin and Provigil kind of opposite? (Klonopin increasing GABA(†) and Provigil (modafinil) decreasing it(‡) ). Does this suggest any danger besides the two possibly counteracting each other's effect to some extent?† sorry, no ref. for this but I believe it's right
‡ "The effects of modafinil on glutamatergic and GABAergic transmission in the rat medial preoptic area (MPA) and posterior hypothalamus (PH), are analysed. Modafinil (30-300 mg/kg) increased glutamate and decreased GABA levels in the MPA and PH."
- from (according to http://www.modafinil.com/glutam.html):
"The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade"
by
Ferraro L, Antonelli T, Tanganelli S, O'Connor WT,
Perez de la Mora M, Mendez-Franco J, Rambert FA, Fuxe K
Department of Clinical and Experimental Medicine,
University of Ferrara, Italy.
Neuropsychopharmacology 1999 Apr; 20(4):346-56-------
Regarding, poop-out:
The information below may explain some cases of Provigil poop-out; in which case a dose increase should restore the effect. Don't know if this would mean dose would have to continue to be increased indefinitely.From: http://www.rxlist.com/cgi/generic2/modafinil_ad.htm#DI
"In a controlled study in patients with narcolepsy, chronic dosing of PROVIGIL at 400 mg/day once daily resulted in a ~20% mean decrease in modafinil plasma trough concentrations by week 9, relative to those at week 3 suggesting that chronic administration of PROVIGIL might have caused induction of its metabolism."peace and health,
S.D.
poster:S.D.
thread:36517
URL: http://www.dr-bob.org/babble/20000603/msgs/36752.html