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Re: Cam--Serotonin-modulated pathways?

Posted by SLS on May 19, 2000, at 13:25:10

In reply to Re: Cam--Serotonin-modulated pathways?, posted by Cam W. on May 18, 2000, at 13:01:31

> medlib & all - The serotonin pathways that are broken down (or disinhibited) are as follows:
>
> Serotonin neurons from the midbrain raphe nuclei to:
>
> Prefrontal Cortex (higher mental activities) - Depression.
>
> Limbic System (incl.limbic cortex and hippocampus) (arousal & motivation) - Panic Disorder.
>
> Basal Ganglia (movement, motor circuitry) - OCD.
>
> Hypothalamus (sugar & fat metabolism) - Bulemia.
>
> These serotonin pathways (between the midbrain raphe nuclei and above structures) are thought to be involved in the above disorders. It is more complicated than this, involving other neurotransmitters and hormones, but this does show serotonin's involvemnet in these disorders.


This is a great summary. All but the prefrontal cortex association surprised me. Thank-you.

Question: Do you think that the prefrontal cortex is involved in SSRI-induced apathy through the stimulation of 5-HT2 receptors located there?

Do you think it is feasible to use small doses of a 5-HT2 antagonist to deal with this? (Remeron, Serzone, Periactin...)? Has anyone described such an effect?

The more of the posts I read between you, PeterJ and medlib, the more of a dummy I feel like. I think this is a good thing. It helps me to remember how educated I am not.

Thanks again.


Sincerely,
Scott

 

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