Posted by JohnL on May 9, 2000, at 4:22:51
In reply to Parnate + amisulpride, Provigil, Mirapex..., posted by SLS on May 8, 2000, at 7:30:18
> Hi all.
>
>
> A recent consultation with a psychiatrist in NYC yielded an old answer to the question of how to treat my refractory bipolar depression.
>
> Parnate.
>
> He thinks I should take Parnate and throw everything possible at it. He was thinking along the lines of using stimulants and dopaminergic drugs.
>
> Any ideas?Though we don't hear too much of these combinations today, they weren't uncommon in the older days. MAOIs + dopamine drugs or norepinephrine drugs don't have nearly the danger of combinations with serotonin drugs. I would think all the combinations you mentioned are quite possible candidates.
You should rule out Amineptine though. A few suppliers still have it in stock--for a while--but it isn't being marketed anymore and will likely run out at some point. I would hate to get better on a drug only to find out I can't get it refilled down the road.
Of the other choices, I think what would be more in line with what they did in the older days would be to add Ritalin or Adderall. Amisulpride or adrafinil could be good choices too, but are not as easy to get. And if you have insurance, it won't cover them. Adding a norepinephrine AD like Desipramine could be considered as well.
Provagil and Mirapex are decent choices too, though they don't have hardly any track record yet for the purposes you mention. In your shoes I would start with just Parnate and see how that goes. It might be all you need. If something else is needed later, then I would look first at the more common things they used to do in the older days. After that I would branch out into uncharted waters. But only after trying more conventional things first. That's just what I would do.
JohnL
>
> I am particularly interested to receive some feedback regarding the following combinations:
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> 1. Parnate + amisulpride or sulpiride
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> 2. Parnate + Provigil (modafinil) or adrafinil
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> 3. Parnate + mazindol (Mazinor)
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> 4. Parnate + amineptine
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> 5. Parnate + Adderal or Desoxyn
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> 6. Parnate + pramepexole (Mirapex)
>
>
> Any and all comments are greatly appreciated.
>
> Thanks.
>
>
> - Scott
poster:JohnL
thread:32745
URL: http://www.dr-bob.org/babble/20000508/msgs/32863.html