Posted by AntRock on May 3, 2000, at 16:04:59
In reply to Re: Parnate+Another Opinion, posted by Adam on May 3, 2000, at 10:39:22
> Ant,
>
> Wow, that's news to me. I have, in the past, wondered about low-dose selegiline/tranylcypromine combinations, but 30mg is hardly a low dose of selegiline. Do you have the name of this doctor? I'm very curious to read about his methods, if there is anything to read.
>
> At any rate, serious adverse reactions to MAOI combinations are, as they say, rare. However, if my memory serves me, when there is an adverse reaction, it can be anywhere from unpleasant to fatal.
>
> I'm also suprised at the idea of a selegiline/tranylcypromine combo at non-specific doses for simple conceptual reasons, and wonder what the rationale is.
>
> I still think Judy's experiences are unlikely to be related to a therapeutic combination of selegiline and Parnate. Again, as I said, if she waited two weeks after stopping selegiline to start Parnate, there should have been essentially no selegiline in her system, and MAO levels should have been approaching normal.
>
> Judy, just as an aside, I don't want to, with my discussion of lithium and its effects on the GABA system, minimize the primary rationale for lithium augmentation of antidepressants, which is the potentiation of serotonergic neurotransmission (though, for instance, the effects of lithium on second messenger systems involved in some serotonin signalling puts an interesting spin on this). The Parnate lithium combo. seems to be especially common, though lithium and Nardil are certainly also used successfully, and this is presumed to be a serotonin-related effect. What I find intriguing about the lithium/Parnate combo. is that, while lithium seems to mediate positive GABAergic effects, GABAergic effects can be antagonized by dopamine, and of particular interest is the dopamine D2 receptor in this feedback system. It is worth noting that Parnate is thought to have strong effects on D2. These two drugs have an intriguing pas de deux.
>
>
Hi Adam,
The Dr.s name is Dr. James Mcknight. I don't know if he as any articles published, but he is out of Georgia. The woman I corresponded with was a patient of his, and she wanted to try deprenyl after reading about the patch trials. She wanted to get off the parnate because of weight gain, but was hesitant because it worked really well for her. So she slowly added deprenyl(oral) to the parnate and had very good success with the combo. She eventually wanted to get off the parnate altogether and just try the deprenyl alone, but I'm not sure she ever did. Anyway her Dr. used this combo with several of his other refractive patients with good results.
I still have the Dr.s phone # if you would like it, just let me know.
Are you still on the parnate Adam?, how is it working? As good as the patch?
I was on & off parnate a couple of times in the last few years. Helped with energy/cognition, but not anhedonia.(Would Lithium help?) I never had problems w/food reactions, and I tested a few of them(cautiosly). I think to much is made out of the whole tyramine diet. It is very easy to abide by the few definite restrictions one needs to follow.
Anyway, I always enjoy reading your posts, even if some parts are over my head.
Take Care,Anthony
poster:AntRock
thread:31946
URL: http://www.dr-bob.org/babble/20000429/msgs/32076.html