Posted by Cam W. on April 28, 2000, at 21:51:56
In reply to Lamictal + Neurontin combination? - duh, spelling, posted by Scott No-Brain Schofield on April 28, 2000, at 20:00:18
Scott - There should be no pharmacokinetic interactions between Lamictal and Neurotic (... er Neurontin - Freudian slip, ya think) as Neurontin is not metabolized to any appreciable extent. A couple of things to keep in mind with these meds, though:1) The risk of Lamictal rash (1/10; Steven-Johnson Syndrome - 1/1000) can be reduced by increasing your Lamictal dose very slowly. I recommend starting with 25mg daily for 1 week; increase to 50mg for the next week and then 50mg twice daily for 2 weeks; then increase by 50mg daily every 2 weeks until target dose is reached (usually 150mg - 200mg total daily dose).
2) Neurontin has a saturable absorption. Single doses in excess 600mg at a time are not appreciably absorbed. It has a short half-life and should be give at least three times daily anyway. For example, if you are taking 3600mg total daily dose, (which I hope you don't need - it is the maximum dose I have seen as a mood stablizer augmentation), you will need to take 600mg - six times daily to ensure full absorption.
You probably know this; I am just reiterating. - Cam W.
poster:Cam W.
thread:31578
URL: http://www.dr-bob.org/babble/20000420/msgs/31621.html