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Re: Wonderful French meds...Scott

Posted by JohnL on April 14, 2000, at 16:18:13

In reply to Re: Wonderful French meds...Adrafinil + Amisulpride., posted by Scott L. Schofield on April 14, 2000, at 10:16:39


>
> Drugs that have worsened my depression:
>
> 1. Lithium - somewhat worse
> 2. Wellbutrin - moderately worse
> 3. Cytomel - much worse
> 4. Vivactil - much worse
> 5. Moclobemide - very much worse
> 6. Reboxetine - much worse
>
>
> I want to thank you for your vigilance in posting your experiences and your evolving suggestions and recommendations. I feel encouraged to see that you have reached such success after suffering so many years of pain, hardship, and discouragement. I have found your contributions, along with those of AndrewB and others to be extremely pertinant to my case.
>
> I am still afraid to hope.
>
>
> - Scott

Scott, your track record looks EXACTLY like mine. Same drugs, same reactions. I think with some of us, the problem isn't that we have low norepinephrine, but rather we have adequate norepinephrine that just isn't working properly. It needs a kick in the butt, some stimulation, some help. Increasing an already adequate level will only cause worsening. But stimulating or enhancing the function of existing norepinephrine is a whole different ballgame. That's what Adrafinil does.

I kind of think of it in this symbolic example. Say for example we want a copper wire to transmit electricity better. What if we could make the density of that wire thicker? That would probably work. But with you and me it actually caused us to get much worse. But what if there was some molecule we could attach to the copper molecules that would make the electricity flow better than with pure copper? That's what Adrafinil does in our brain. It just makes the norepinephrine system work better than it does on its own. The Adrafinil molecules attach to certain brain molecules and then everything works better, especially if those certain brain molecules are somehow subactive to begin with.

That's just my layman interpretation. If you decide to try it, I'm cheering for you! JohnL


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