Posted by AndrewB on March 11, 2000, at 14:51:34
In reply to Re: Q for Andrew - fatigue/depression, posted by michael on March 10, 2000, at 17:54:34
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> I was just wondering if you had any insights/info regarding amantadine, as an augmenter. I've seen it mentioned in the past with respect to helping to overcome some of the sexual side effects.
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> The reason I'm asking is that I believe it too affects dopamine, and that when it is broken down by the body, a couple of the by-products that result are stimulant-like, giving it a small energizing effect. Just wondering.
Michael,Amantadine does have dopamine properties (prevents reuptake at the D1 & D2 receptors). It also has serotonergic and noradrenergic activity as well as being an anti-viral and having other activity. It has been speculated to have some antidepressant activity (because it helps with depression associated with borna virus?). Does anyone know of anyone using it for this purpose. It is used by MS patients to combat their fatigue. It is also used to treat apathy asociated with stroke and frontal lobe syndrome. As you said it is used to sounteract SSRI sexual side effects as well as SSRI poop out. Supposedly amantadine has significant side effects so it maybe isn't the the best choice for dealing with D2 receptor based fatigue.
poster:AndrewB
thread:25780
URL: http://www.dr-bob.org/babble/20000302/msgs/26698.html