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Re: Which ADs affect dopamine and norepinephrine?

Posted by Scott L. Schofield on January 30, 2000, at 14:59:24

In reply to Re: Which ADs affect dopamine and norepinephrine?, posted by Sigolene on January 30, 2000, at 13:27:24


> Hi,

> I'm very impressed by your post !

Don't say things like that. I might begin to think that I have a brain.

> Where did you get all these knowledge about medications ?

1. Rutgers Medical School Library - a long time ago.
- I was able to concentrate and remember things better then than I can now. Even so, I was only able to work for between 30 and 45 minutes before my poor brain would give up and force me to go home.

2. For several reasons, I felt very strongly that dopamine function played a critical role in my case. At the time, only a handful of investigators were looking into it as possibly being a contributing factor in the causes of depression. That is why I began to search for antidepressants or other drugs that possessed dopaminergic and norandrenergic properties.

2. I have seen too many doctors, although I feel very fortunate to have had the opportunity.

3. I guess if you throw enough sh_t against the wall, some of it is bound to stick.


> Just one thing: I think that MAOI also affect serotonin, as well as NE and DA.Am I wrong ?


No, you are not wrong. Either that, or we are both wrong.

Serotonin (5-HT), norepinephrine (NE), and dopamine (DA) all belong to a family of molecules known as "monoamines". Monoamine oxidase (MAO) is an enzyme that is supposed to break-down these neurotransmitters to keep their levels stable. If MAO is prevented from doing so (inhibited), levels neurotransmitters increase.

Additionally, those MAOIs that can inhibit the MAO-A subtype enzyme, raise the levels of melatonin in the brain (pineal gland) by stimulating its biosynthesis.

- Scott


It's getting close to kick-off.


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poster:Scott L. Schofield thread:19950
URL: http://www.dr-bob.org/babble/20000128/msgs/20114.html