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Re: Marplan and insomnia (or something)

Posted by Adam on December 15, 1999, at 23:35:09

In reply to Marplan and insomnia (or something), posted by Elizabeth on December 15, 1999, at 21:47:11

I'm afraid it's the pindolol. I'm sorry I didn't mention this earlier. In my travels through the wonderful world of potential drug augmentation strategies for OCD I came across this side effect and guessed that if I wanted to stay on selegiline or switch to tranylcypromine pindolol was NOT the thing to try (and anyway, it wouldn't do what I want). To wit...

J Pharmacokinet Biopharm 1995 Apr;23(2):131-45

Prediction of sleep disorders induced by beta-adrenergic receptor blocking agents based on receptor occupancy.

Yamada Y, Shibuya F, Hamada J, Sawada Y, Iga T
Department of Pharmacy, University of Tokyo, Japan.

As for the munchies, I'm baffled. I thought pindolol would help prevent that, no? (antagonizing presynaptic 5-HT1A, helping to stimulate postynaptic 5-HTeverything)

I'm essentially a notcturnal creature these days too. It was fun at first, but now it just sucks. I probably need some zolpidem as well, but I can't really have any right now.

Meanwhile my roomates are thinking of hanging some garlic over my bed and spritzing me with holy water to see what would happen.

> I'm having something really odd going on. I'm taking Marplan 40mg, lithium 300mg b.i.d. (now trying to d/c it - switching to 300 q.d. tomorrow), and pindolol 5mg b.i.d. I have the worst insomnia-or-something I've ever had when not depressed! I've been alternating between sleeping maybe 2-4 hours one night and not sleeping at all the next. Also it's initial as well as terminal/late insomnia, which is not typical for me either (while depressed or not).
> It gets weirder. I'm getting food cravings starting at night and through the middle of the night. (Not overeating or gaining weight, but they are usually cravings for sweets.) I feel more awake and alert in the middle of the night than in the day...I feel like I should be asleep in the daytime, and sometimes I do sleep in the day, but I've been trying not to do this and I still have lots of trouble getting to sleep at night (often can't at all). Has anyone experienced this (especially the day-night reversal thing), and if so do you have any idea what causes it?
> My pdoc wrote me a script for some more Ambien (20mg/night) today; I hope it works again this time (I used it the whole time I was on Nardil, but the insomnia wasn't as bad that time).




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