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Re: Inositol, Part II

Posted by Adam on December 9, 1999, at 12:27:41

In reply to Re: Inositol, Part II, posted by jamie on December 9, 1999, at 3:43:31

Hey, Jamie,

I read about the effects of lithium on phoshphatidylinositol turnover, and how that might
be one explanation for its "paradoxical effects" on serotoninergic signalling. It's very
interesting. I'm hoping mania isn't a problem. Selegiline can make me kind of hyper,
but that's probably it.

The OCD study I cited used 18(!)g/day of inositol, dissolved in juice. One thing nice about
the study is the subjects couldn't distinguish it from the glucose control. To think, a
sugar that isn't the placebo.

That's definitely good advice about ramping the dose, though my guess also is there should
be no problems in conjunction with an MAOI. Where did you get the 500mg pills? Did you
need a prescription? Was it expensive? And lastly, did it do anything for you besided be
inconvenient :)? Thank you!

> If I remember correctly, doses needed are about 12g a day. Since the pills are 500mg, that's 24 pills a day! That's a lot of pills to carry around. But if it works I guess it's worth it. I think inositol is also available as a powder for larger dosing. I tried it once, but found taking in 12g a day to be an incredible chore.
> There is a theory that excess inositol is implicated in mania. And that one way lithium works in mania is by inhibiting inositol. By the way, inositol is a lot like a sugar. I found I could mix it in coffee just like sugar and it tasted the same. I don't think inositol would be dangerous with maois, though it would be wise probably to try one 500mg pill, then two, then three, etc...feel it out carefully. It's not heavily studied, so I doubt anyone knows for sure about inositol in general or in combination with maois. I just suspect its indirect nutritive action would have no compatability problems with maois. After all, it's basically just a version of sugar.




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