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Re: Please read, many apologies...

Posted by Adam on November 15, 1999, at 12:40:45

In reply to Re: What the h* are *topical* ketoconazoles, posted by Adam on November 15, 1999, at 12:24:48

Actually, I was completely wrong about citalopram and cytochrome P450. It is
metabolized by members of this family, and ketoconazole can indeed interfere
with this. Citalopram is itself thought to inhibit CPs less than some other
SSRIs (and thus be a better choice for the elderly, who often are taking lots
of other medications), but my impression that it was not a concern was totally

> Ketoconazole is used primarily as an antifungal agent, and can be administered orally
> or topically (in a shampoo or a cream). It is a potent inhibitor of many members of the
> cytochrome P450 family of enzymes, which are involved in the metabolism of a wide variety
> of drugs, largely in but not limited to the liver. Oral ketoconazole can cause problems
> if used in combination with other drugs. Topical ketoconazole isn't a problem.
> > DJ! You actually made me laugh for the first time in over a week, Yeah!! I think the subject has to do with dandruff and scalps and topical solutions placed onto the head to combat the aforementioned.
> >
> > dove




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