Posted by Rick on November 11, 1999, at 0:13:51
Am I missing something here? Has there been ANOTHER Parke-Davis-funded study that showed more impressive Social Phobia response than the report released in August? This study showed response rates that may be statistically significant, yet are less than seen for SSRI's and far, far less than seen in large-scale controlled studies of Nardil and Klonopin which each produced 70-80% improvement vs. 20% for placebo. If there's been a more recent study, could someone let me know where to locate it? Thanks.
Meanwhile, here is an excerpt from the write-up which has me less than impressed with Neurontin (31% improvement vs. 14% for placebo).
-----------Results of a new study, published in the Journal of Clinical Psychopharmacology (JCP), found that patients suffering from social phobia experienced a decrease in symptoms by an average of 31 percent after treatment with Neurontin (gabapentrin), compared to only a 14 percent reduction in patients treated with placebo.
Research for the study was conducted at Duke University in Durham, North Carolina, and the Dean Foundation of Health, Research and Education in Middleton, Wisconsin, and was supported by the Parke-Davis Division of Warner-Lambert Company. The study also showed that the drug was generally well tolerated.
Historically, social phobia has been treated with a number of drugs, most notably selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and anti-anxiety agents (benzodiazepines)," explained Dr. Greist. "In the study, gabapentin was shown to significantly reduce the symptoms of this disorder."The most common adverse events during the study in social phobia were infection (29 percent vs. 23 percent with placebo); headache (24 percent vs. 26 percent with placebo); dizziness (24 percent vs. 6 percent with placebo); somnolence (21 percent vs. 9 percent with placebo); nervousness (15 percent vs. 11 percent with placebo); weakness (15 percent vs. 9 percent with placebo); dry mouth (12 percent vs. 0 percent with placebo)
poster:Rick
thread:14991
URL: http://www.dr-bob.org/babble/19991108/msgs/14991.html