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Re: Buspar + Pindolol?

Posted by JohnB on June 29, 1999, at 14:43:04

In reply to Buspar + Pindolol?, posted by JohnL on June 29, 1999, at 4:11:50

No, I've never tried this combination nor have I been on either med individually. Pindolol is an interesting drug to study. I just read a study in Neuropharmacology (Vol 38, Iss 6 1999) indicating that pindolol seems to "increase(s) dialysate [extracellular] concentrations of dopamine and noradrenaline, but not serotonin, in frontal cortex of freely-moving rats." Pindolol is a partial agonist at 5HT-1A receptors, agonist and antagonist properties at 5HT-1A autoreceptors, a partial agonist at B-Adrenergic receptors and an antagonist at 5HT-1B receptors, a profile of action, the study suggests, that might influence the dopaminergic and adrenergic pathways. This appears to be a far more complicated profile than its indicated use for high blood pressure would suggest.
By the way, where can I read about the NYU info. you mentioned? Thanks for the great information.





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