Psycho-Babble Medication | about biological treatments | Framed
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Re: q for Mr. or Ms. Anon

Posted by Adam on October 19, 1999, at 14:57:57

In reply to q for Mr. or Ms. Anon, posted by Elizabeth on October 19, 1999, at 12:53:14

I also am curious. I have thought for a couple months now that a combination of an MAOI and reboxetine might be a very potent
antidepressant therapy, if such a combination proves to be safe. Especially for those with the "endogenous" or "melancholic"
type of depression, with maybe some atypical features, I have a hard time thinking of a better way to enhance the noradrenergic
response whilst minimizing adverse side effects. One favorite coctail I have dreampt up in my head is selegiline plus reboxetine.
Selegiline is activating, highly dopaminergic, probably less robust in boosting NA and 5-HT than other MAOIs, but a good mood
elevator for me, and apparently others. Combine that with the supposedly drive-enhancing effects of reboxetine, and you might
just end up with a happier, more productive person. Parnate might do well in place of selegiline in this little scheme of mine.
I know plenty of other people have thought of the same thing, and all that remains is to test it.

I sure hope reboxetine is the real deal. I also wish it would get approved ASAP. I'd much rather take such a combo than, say,
an MAOI plus desipramine. I have had horrible reactions to TCAs, and have basically concluded that I can't tolerate them.
Reboxetine just sounds like a great addition to the pharmacopia.

> > Why? Well, the FDA is concerned enough about one of its side effects to ask for physician monitoring of this side effect while the patient is taking Reboxetine.
> Since you seem to know so much about this, what is the side effect in question?




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