Posted by D.C on August 11, 1999, at 8:17:36
In reply to Re:MAOI Type A or B?, posted by Adam on August 9, 1999, at 19:23:10
>
It doesn't do squat compared to the other MAOI's. Yeah I've heard about all the supposed health benefits, intelligence boosting etc. It strikes me as rather odd. Ritalin is more likely to get your mind pumping from what I hear. I don't know though maybe it's just my own biochemistry. It would be nice though to get a drug that could boost your brain power. Anyone know of any?
In my last post, what I meant to say was "I have seen nothing in the literature that clearly demonstrates
> that THE robust dopaminergic effect is of any real benefit in treating depression", meaning the MAO-B
> inhibatory effects of selegiline. Many drugs that are "dopaminergics" like ritalin and amineptine have
> been shown to be effective in treating depression, sometimes alone, or sometimes in combination with
> other drugs. I apologise for my poor choice of wording.
>
> >
> > > What is the difference between a type A or B Maoi? If type A helps with your mood what does type B help with?
> > >
> > > Thanks,
> > > Robin
> >
> > MAO-A is found throughout the body, including the gut, and largely deaminates
> > serotonin and norepinepherine (as well as tyramine in the gut), though it does
> > have some low and non-specific activity on dopamine. MAO-B is found in the brain
> > and primarily deamniates dopamine.
> >
> > I have read that inhibition of MAO-B alone is not sufficient for the treatment of
> > depression, and in the case of selegiline, low doses (5mg/day, when there is only
> > inhibition of MAO-B) are not sufficient for that indication. However, selegiline
> > has been shown to be efficacious at higher doses, where MAO-A is also inhibited.
> > There may be a benefit in the dopaminergic effects of selegiline in addition to
> > its serotonergic and norepinepherinergic effects. For example, as some have posted
> > above, it may improve some cognitive functioning and sex drive.
> >
> > This is all anecdotal, of course. I have seen nothing in the literature that clearly
> > demonstrates that a robust dopaminergic effect is of any real benefit in treating
> > depression.
poster:D.C
thread:5905
URL: http://www.dr-bob.org/babble/19991001/msgs/9895.html