Posted by AMY II on October 13, 1999, at 13:59:21
In reply to Amy - How are You? found some info for you!, posted by dove on October 12, 1999, at 9:31:54
> Amy, I hope you're doing better? Just thought I would pass this info on to you. Let us know how you're doing. My thoughts are with you.
> ~dove
>
>
> MDMA or Ecstasy
>
> "3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") was first synthesized 80 years ago (Green et al 1995). It has recently received prominence as an recreational drug of abuse. There is a belief among misusers that it is safe. In the last 2-3 years there have been a number of reports of the drug producing severe acute toxicity and death and there are concerns that it may cause long term toxic damage to 5-hydroxytryptamine (5-HT) nerve terminals.
>
> Acute clinical toxicity results in a serotonin syndrome that can be fatal. The recent increase in the number of reports of MDMA toxicity probably results from the widespread use of the drug at all night dance parties or "raves". The phenomenon of amphetamine aggregation toxicity in mice was reported 40 years ago. If applicable to MDMA-induced toxicity in humans, all the conditions necessary to induce or enhance toxicity are present at raves: crowded conditions (aggregation), high ambient temperature, loud noise and dehydrated subjects. Administration of MDMA to rodents and non-human primates results in a long term neurotoxic decrease in 5-HT content in several brain regions and there is clear biochemical and histological evidence that this reflects neurodegeneration of 5-HT terminals. Unequivocal data demonstrating that similar changes occur in human brain do not exist, but limited and indirect clinical evidence gives grounds for concern.
>
> Psychiatric disturbances associated with MDMA abuse include depression, panic attacks, visual illusions, and paranoid psychosis. Suggestions for the rational treatment of the acute toxicity are made on the basis of both pharmacological studies in animals and current clinical practice.
>
> Cases presenting clinically are usually emergencies and unlikely to allow carefully controlled studies. Proposals include decreasing body temperature (possibly with ice), the use of dantrolene and anticonvulsant and sedative medication, particularly benzodiazepines."Thank you for checking on me. However i am doing no better. Up to 100 mg of zoloft and not feeling a difference. Off ativan now and feel horrible. My eyes never sto dialating. Weird dreams dont stop. Twitching hasnt gotten any better. chest pain...worse. I was wondering, I am having a hard time comprehending everything you sent to me so does that mean "long term" as in not permenant damage? I wish I could talk to these people that are doing these studies. I swear I am one for the books. And does this mean that I might have this seratonin syndrome that can be fatal? I am confused. Please respond as quickly as possible. What saratonin syndrome is there? I definately feel I have damage to my nerves, that is for sure. By the way slept for 14 hours today. I hate this zoloft. I loved ativan. Even though it started not to work as well for me. I sure felt more normal on that than i do now. I feel no absolutely no difference. It's been almost a month. I am scared of this new information. Please tell me where you got it and maybe I can present it to my doctor and they can look into it. Instead of just thinking i have anxiety. I then can download it and print it out. I cant do that on this site. Thanks so much. It means alot. Keep in touch guys. Hangin on, AMY II
poster:AMY II
thread:11898
URL: http://www.dr-bob.org/babble/19991001/msgs/13090.html