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High Dose Selegiline (Deprenyl) for Social Phobia?

Posted by John on September 9, 1999, at 12:10:53

Hi,

Anyone with experience with "high dose," 60 mg/day or greater, Selegiline (Deprenyl) for social phobia? My thinking is that it could be an alternative to Nardil and Parnate if taken as the higher doses where it loses its MAO-B selectivity (>10-15 mg/day). I've seen some threads on what I think is this site (the old RxQx) where practictioners mentioned using up to 60 mg/day of Selegiline in successfully treating depression. So the question: at this level, how does it compare to the "gold standard" Phenelzine? ANYONE WITH EXPERIENCE? By the way, I'd stick with Phenelzine if it didn't leave me with erectile dysfunction (at the slightest dose), anorgasmia (I guess that's secondary to erectile dysfunction - uh, one needs to happen before the other), and gaining 15 lbs. plus. Lastly, I understand that Liebowitz, et al., of the New York State Psychiatric Institute found the reversible MAO inhibitors (RIMA's), namely Moclobemide, to be no better than placebo in their more recent follow-up studies.

Thanks.


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poster:John thread:11298
URL: http://www.dr-bob.org/babble/19990914/msgs/11298.html