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Re: over the counter antidepressants

Posted by John on September 9, 1999, at 12:25:15

In reply to Re: over the counter antidepressants, posted by BRS on September 6, 1999, at 21:55:57

> > Hello, Bob! Great website! I hope you are well since our APA meeting...I am writing to see if anyone out there has case vignettes of patients experiencing manic, psychotic, or other adverse neuropsychiatric reactions to over-the-counter "antidepressants", including but not limited to St. John's Wort, SAM-e, ma huang (ephedra), etc. I am collating cases for an article on this topic, and would cite any vignettes as a "personal communication" from the author, unless he/she did not wish to be cited. I can also be reached at PO Box 332, Bedford MA 01730---Thanks much! Best, Ron Pies MD (Tufts USM)
> I've heard that combining 5-htp with St. John's wort can lead to serotonin syndrome in specific cases of high doses. You also need to be careful of the herbs licorice and schizandra because they do have subtle effects on serotonin synthesis and can cause problems if used with pharmaceutical antidepressants. Sam-e is strange because it has been found that depressed individuals do have lower sam levels, but they are markedly increased after treatment with a pharmaceutical antidepressant, which leads me to believe that Sam isn't the cause of depression, but just a intermediary factor.

Hi, hope you're able to identify the specific compounds under which "adverse events" are anecdotally reported. I've tried strictly the formulations which are the patented compounds cited in the clinical research trials found in a Medline search. Notably, these are Ginkgo Biloba (EGb 761), brand name Ginkgoba (Pharmaton - division of Boehring-Ingleheim), Ginsana (GS-115, Pharmaton), SJW (LI-160 - Lictwer; WS-5572 Pharmaton). I would think the number of adverse events would be low with these heavily used compounds, as long as users are communicating with their physicians when taking concommitantly with other meds).




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