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Re: weight gain/pharmaceutical research

Posted by Elizabeth on August 13, 1999, at 0:28:20

In reply to Re: weight gain/pharmaceutical research, posted by Annie McNeil on August 12, 1999, at 0:26:28

The trouble with the data from clinical trials intended to establish efficacy is I don't think they specifically monitor weight the way that the study published in AJP did. People may not spontaneously report weight gain, especially in short trials.

I don't blame you guys for not trusting Eli Lilly (does *anybody* trust them? I wonder if they realize just how untrusted they are? ), but I know the work of some of the authors of this paper and don't believe them to be puppets of the industry. No doubt sometime I will be accepting a grant from a pharmaceutical company to study one of their products; I don't have any intention of doing so if it's conditional on getting the results they want.

Someone asked whether some SSRIs are worse than others. I think the answer may be yes; it seems to me that Paxil is the worst.

People do tend to gain weight in the long run, particularly if their mood is not stable. People tend to gain weight when they recover from depression. I'm therefore suspicious even of fairly frequent reports by doctors or patients describing antidepressant-"induced" weight gain. (Kind of like reports that some therapy worked when clinical trials support the notion that the therapy is no better than a placebo.)




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