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Re: Reboxetine (Edronax)

Posted by Susan on October 18, 1998, at 23:13:36

In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03

> For treating dysthmic disorder Effexor has worked much better than other SSRI have. Works well except for the sexual side effects. I am planning to try Reboxetine (Edronax) any information on this norepinephrine re-uptake inhibitor would be appreciated. I am hoping to get a good response minus the side effect.

Here's some info I found at

I'm not clear, is Roboxetine available in the United States? Are there other drugs within the NARI category that might be more effective for those with melancholic symptoms? This is certainly an option I'd like to talk to my doctor about if it's available.

Reboxetine (Edronax) is an interesting and highly selective
"noradrenergic" agent. Crudely, whereas serotonin plays a vital role in mood,
noradrenaline is essential to maintaining drive and the capacity for reward. There's
a fair bit of evidence that chronically depressive people have dysfunctional and
atypical noradrenergic systems - particularly their alpha 2- and
beta-adrenoceptors. The vastly ramifying central noradrenaline system regulates
alertness and the sleep-wakefulness cycle. It's involved in autobiographical
memory, learning and attention; degree of mental focus; cerebral plasticity and
neuro-protection; and, obscurely but not least, our sensitivity to rewarding
experience and tendency to melancholia or elation. Reboxetine itself doesn't have
disruptive effects on cognitive function and psychomotor performance. These are
annoyingly typical of many traditional clinical mood-brighteners. Indeed the new
NorAdrenaline Reuptake Inhibitors (NARIs) are probably massively under-used
and under-hyped. NARIs and dopaminergics may be especially good for
drive-deficient "anergic" states where the capacity for sustained motivation is
lacking; and for melancholic depressives with a poor ability to cope with stress.
Perhaps surprisingly, preliminary studies suggest reboxetine can actually reverse
tranylcypromine-induced hypertensive crises. The "cheese effect" is usually
triggered by ingesting tyramine-rich foods. Thus NARIs plus MAOIs may prove a
potent form of combination-therapy, at least for those who don't mind their
cocktails well-mixed.




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